Sepehr Ehsani

[PREPRINT ARTICLEEhsani S (2019). "The challenges of purely mechanistic models in biology and the minimum need for a 'mechanism-plus-X' framework". arXiv:1905.10916v1.

[Nov. 2018]  Presented at The Mechanistic Approach in Biology and Cognition Workshop (Link), Center for Philosophy of Sciences, University of Lisbon, Portugal
[ PDF ]    [ arXiv ]


[BOOK REVIEW]  Ehsani S (2018). "Relativism as a means to alleviate biology from genomic reductionism: But is the remedy effective?Metascience 27(1), 111-115.
[ PDF ]    [ Journal ]


[RESEARCH ARTICLE]  Khurana V, Peng J, Chung CY, Auluck PK, Fanning S, Tardiff DF, Bartels T, Koeva M, Eichhorn SW, Benyamini H, Lou Y, Nutter-Upham A, Baru V, Freyzon Y, Tuncbag N, Costanzo M, San Luis BJ, Schöndorf DC, Barrasa MI, Ehsani S, Sanjana N, Zhong Q, Gasser T, Bartel DP, Vidal M, Deleidi M, Boone C, Fraenkel E, Berger B, Lindquist S (2017). "Genome-scale networks link neurodegenerative disease genes to α-synuclein through specific molecular pathways". Cell Syst 4(2), 157-170.
[ PDF ]    [ Journal ]


[RESEARCH ARTICLE]  Brethour D, Mehrabian M, Williams D, Wang X, Ghodrati F, Ehsani S, Rubie EA, Woodgett JR, Sevalle J, Xi Z, Rogaeva E, Schmitt-Ulms G (2017). "A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition". Sci Rep 7, 40313.
[ PDF ]    [ Journal ]


[PREPRINT ARTICLEEhsani S (2016). "A framework for philosophical biology". arXiv:1605.00033v1.

[May 2017]  Presented at the Annual Meeting of the Canadian Society for the History and Philosophy of Science (Link), Ryerson University, Toronto, Ontario, Canada
[ PDF ]    [ arXiv ]


[PREPRINT ARTICLEEhsani S (2015). "Identification of the Zeo1 protein as a candidate structural homolog of α-Synuclein in budding yeast". arXiv:1505.03196v1.
[ PDF ]    [ arXiv ]    [ Abstract ]


[REVIEW ARTICLENarayan P*, Ehsani S*, Lindquist S (2014). "Combating neurodegenerative disease with chemical probes and model systems". Nat Chem Biol 10(11), 911-20.
[ PDF ]    [ Journal ]


[PERSPECTIVE ARTICLEMehrabian M, Ehsani S, Schmitt-Ulms G (2014). "An emerging role of the cellular prion protein as a modulator of a morphogenetic program underlying epithelial-to-mesenchymal transition". Front Cell Dev Biol 2, 53.
[ PDF ]    [ Journal ]


[RESEARCH ARTICLEPocanschi CL, Ehsani S, Mehrabian M, Wille H, Reginold W, Trimble WS, Wang H, Yee A, Arrowsmith CH, Bozóky Z, Kay LE, Forman-Kay JD, Rini JM, Schmitt-Ulms G (2013). "The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer". PLOS ONE 8(9), e72446.
[ PDF ]    [ Journal ]


[PREPRINT ARTICLEEhsani S (2013). "Correlative-causative structures and the ‘pericause’: an analysis of causation and a model based on cellular biology". arXiv:1310.0507v1.

[Jul. 2014]  Presented at the Annual Meeting of the International Society for the Philosophy of Chemistry (Link), The London School of Economics, London, United Kingdom
[ PDF ]    [ arXiv ]


[PREPRINT ARTICLEEhsani S (2013). "Macro-trends in research on the central dogma of molecular biology". arXiv:1301.2397v2.
[ PDF ]    [ arXiv ]


[RESEARCH ARTICLEEhsani S*, Salehzadeh A*, Huo H*, Reginold W, Pocanschi CL, Ren H, Wang H, So K, Sato C, Mehrabian M, Strome R, Trimble WS, Hazrati LN, Rogaeva E, Westaway D, Carlson GA, Schmitt-Ulms G (2012). "LIV-1 ZIP Ectodomain Shedding in Prion-Infected Mice Resembles Cellular Response to Transition Metal Starvation". J Mol Biol 422(4), 556-74.
[ PDF ]    [ Journal ]


[PERSPECTIVE ARTICLEEhsani S, Mehrabian M, Pocanschi CL, Schmitt-Ulms G (2012). "The ZIP-Prion Connection". Prion 6(4), 317-21.
[ PDF ]    [ Journal ]


[RESEARCH ARTICLEHarbi D, Parthiban M, Gendoo DM, Ehsani S, Kumar M, Schmitt-Ulms G, Sowdhamini R, Harrison PM (2012). "PrionHome: a database of prions and other sequences relevant to prion phenomena". PLOS ONE 7(2), e31785.
[ PDF ]    [ Journal ]


[PREPRINT ARTICLE]  Ehsani S (2012). "Time in the cell: a plausible role for the plasma membrane". arXiv:1210.0168v1.

[Oct. 2012]  MIT Technology Review commentary (Link)

[Feb. 2013]  Presented at the 4th Annual UCSD Center for Chronobiology Symposium: From Cells to Clinic (Link), San Diego, California, United States
[ PDF ]    [ arXiv ]    [ Poster ]


[PREPRINT ARTICLEEhsani S (2012). "Simple variation of the logistic map as a model to invoke questions on cellular protein trafficking". arXiv:1206.5557v1.
[ PDF ]    [ arXiv ]


[RESEARCH ARTICLEEhsani S*, Tao R, Pocanschi CL, Ren H, Harrison PM, Schmitt-Ulms G* (2011). "Evidence for retrogene origins of the prion gene family". PLOS ONE 6(10), e26800.
[ PDF ]    [ Journal ]


[RESEARCH ARTICLEKnobbe CB, Revett TJ, Bai Y, Chow V, Jeon AH, Böhm C, Ehsani S, Kislinger T, Mount HT, Mak TW, St George-Hyslop P, Schmitt-Ulms G (2011). "Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90". J Proteome Res 10(10), 4388-404.
[ PDF ]    [ Journal ]


[REVIEW ARTICLEEhsani S, Huo H, Salehzadeh A, Pocanschi CL, Watts JC, Wille H, Westaway D, Rogaeva E, St George-Hyslop PH, Schmitt-Ulms G (2011). "Family reunion - the ZIP/prion gene family". Prog Neurobiol 93(3), 405-20.
[ PDF ]    [ Journal ]


[PREPRINT ARTICLEEhsani S (2011). "Consciousness and subjective time: a plausible auditory approach". Nature Precedings hdl:10101/npre.2011.5941.1.
[ PDF ]    [ Journal ]


[RESEARCH ARTICLEWatts JC*, Huo H*, Bai Y*, Ehsani S*, Won AH, Shi T, Daude N, Lau A, Young R, Xu L, Carlson GA, Williams D, Westaway D, Schmitt-Ulms G (2009). "Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones". PLOS Pathog 5(10), e1000608.
[ PDF ]    [ Journal ]


[RESEARCH ARTICLESchmitt-Ulms G*, Ehsani S, Watts JC, Westaway D, Wille H (2009). "Evolutionary descent of prion genes from the ZIP family of metal ion transporters". PLOS ONE 4(9), e7208.
[ PDF ]    [ Journal ]    [ Press Release ]


[PREPRINT ARTICLEEhsani S, Croul SE, Knight K, Kiehl TR (2009). "Seasonal patterns of presentation in primary malignant brain tumors and metastases based on a retrospective neuropathologic database". Nature Precedings hdl:10101/npre.2009.2969.1.

[May 2008]  Presented at the 13th Biennial Canadian Neuro-Oncology Meeting, Banff, Alberta, Canada
[ PDF ]    [ Journal ]


[RESEARCH ARTICLEEhsani S, Hodaie M, Liebsch NJ, Gentili F, Kiehl TR (2008). "Anaplastic glioma after high-dose proton-photon radiation treatment for low-grade skull base chondrosarcoma". J Neurooncol 88(2), 231-236.
[ PDF ]    [ Journal ]


[RESEARCH ARTICLEEhsani S, Kiehl TR, Bernstein A, Gentili F, Asa SL, Croul SE (2008). "Creation of a retrospective searchable neuropathologic database from print archives at Toronto's University Health Network". Lab Invest 88(1), 89-93.

[Apr. 2007]  Presented at Experimental Biology 2007, Washington, D.C., United States
[ PDF ]    [ Journal ]



Other Contributions


[2014]  External Reviewer, Proceedings of the First International Conference of Algorithms for Computational Biology

[ Proceedings ]


[2012]  Comment on "The trouble with time travel" (Kumar, New Scientist 7 Dec 2011)

[ Comment ]


[2008]  Co-Editor-in-Chief, University of Toronto Journal of Undergraduate Life Sciences (JULS)

[ PDF of 2008 issue ]

From the 2009 issue:

[ PDF of 2009 issue's front matter ]

[ PDF of interview with Gopal Sreenivasan in 2009 issue ]

[ PDF of "Neuropathology in Its Second Century" by Sidney E. Croul in 2009 issue ]